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- Title
Short- and Long-Term Changes in Health-Related Quality of Life with Weight Loss: Results from a Randomized Controlled Trial.
- Authors
Wadden, Thomas A.; Tronieri, Jena Shaw; Leonard, Sharon M.; Carvajal, Raymond; Bakizada, Zayna M.; Pinkasavage, Emilie; Gruber, Kathryn A.; Walsh, Olivia A.; Pearl, Rebecca L.; Berkowitz, Robert I.; Chao, Ariana M.; Alamuddin, Naji; Alfaris, Nasreen
- Abstract
<bold>Objective: </bold>The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial.<bold>Methods: </bold>Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program. The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) scale (including five subscales), Patient Health Questionnaire-9 (depression), and Perceived Stress Scale were administered at the start of the 14-week LCD program, randomization, and week 52 of the randomized controlled trial (i.e., 66 weeks total).<bold>Results: </bold>Significant improvements in all outcomes, except weight-related public distress, were found following the 14-week LCD program (P values < 0.05). Improvements were largely maintained during the 52-week randomized controlled trial, despite weight regain of 2.0 to 2.5 kg across treatment groups. Participants who lost ≥ 10% of initial weight achieved greater improvements in physical function, self-esteem, sexual life, and the IWQOL-Lite total score than those who lost < 5% and did not differ from those who lost 5% to 9.9%.<bold>Conclusions: </bold>Improvements in weight-specific health-related quality of life were achieved with moderate weight loss and were sustained during WLM.
- Subjects
WEIGHT loss; HEALTH; OBESITY; RANDOMIZATION (Statistics); STRESS management
- Publication
Obesity (19307381), 2018, Vol 26, Issue 6, p985
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22187