We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ocular Histopathologic Features of Congenital Zika Syndrome.
- Authors
Fernandez, Maria P.; Saad, Edgar Parra; Martinez, Martha Ospina; Corchuelo, Sheryl; Reyes, Marcela Mercado; Herrera, Maria Jose; Saavedra, Miguel Parra; Rico, Angelica; Fernandez, Angela M.; Lee, Richard K.; Ventura, Camila V.; Berrocal, Audina M.; Dubovy, Sander R.; Parra Saad, Edgar; Ospina Martinez, Martha; Mercado Reyes, Marcela; Parra Saavedra, Miguel
- Abstract
<bold>Importance: </bold>Congenital Zika syndrome (CZS) is known to be associated with severe malformations in newborns. Although microcephaly is the hallmark of this disease, the ocular findings are important given the severe visual impairment that has been observed in these patients. Regardless of the increased number of CZS cases reported, to date, no studies have described the ocular histopathologic findings of this entity.<bold>Objectives: </bold>To evaluate the presence of Zika virus (ZIKV) antigens and describe the associated ocular histopathologic features of 4 cases of CZS.<bold>Design, Setting, and Participants: </bold>In this observational case series performed from June 19, 2015, through April 30, 2017, ocular tissue samples from 4 deceased fetuses with a diagnosis of CZS from the National Institute of Health in Colombia were sent to the Florida Lions Ocular Pathology Laboratory for evaluation.<bold>Main Outcomes and Measures: </bold>The microscopic features of each specimen were described, and immunostaining was performed using a ZIKV NS2B protein antibody.<bold>Results: </bold>Ocular tissue samples from the 4 deceased fetuses (2 female, 2 male) ranging from 21.5 to 29 weeks' gestation with a diagnosis of CZS were studied. The 4 eyes manifested with pupillary membranes, immature anterior chamber angles, loss of pigment and thinning of the retinal pigment epithelium, choroidal thinning, undifferentiated nuclear layers of the retina, and a perivascular inflammatory infiltrate within the choroid. The optic nerve, present in 2 of the eyes, demonstrated atrophy. Expression of ZIKV antigen was present in the iris in cases 1, 3, and 4; the neural retina and choroid in case 1; and in the optic nerve in case 4.<bold>Conclusions and Relevance: </bold>Loss of retinal pigment epithelium, the presence of a thin choroid, a perivascular choroidal inflammatory infiltrate, and atrophic changes within the optic nerve were consistently present. These findings may be attributed to ZIKV infection and warrant further study.
- Subjects
DIAGNOSIS of fetal diseases; DNA analysis; ABORTION; COMMUNICABLE diseases; DIFFERENTIAL diagnosis; FETAL diseases; FLUORESCENT antibody technique; IMMUNOHISTOCHEMISTRY; POLYMERASE chain reaction; PREGNANCY complications; PRENATAL diagnosis; SYNDROMES; VIRAL antigens; RETROSPECTIVE studies; VIRAL eye infections; DIAGNOSIS
- Publication
JAMA Ophthalmology, 2017, Vol 135, Issue 11, p1163
- ISSN
2168-6165
- Publication type
journal article
- DOI
10.1001/jamaophthalmol.2017.3595