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- Title
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport.
- Authors
Kobayashi, Toshihide; Beuchat, Marie-Hélène; Lindsay, Margaret; Frias, Sonia; Palmiter, Richard D.; Sakuraba, Hitoshi; Parton, Robert G.; Gruenberg, Jean
- Abstract
The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Here we report that late endosomes have a pivotal role in intracellular cholesterol transport. We find that in the genetic disease Niemann -- Pick type C (NPC), and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired. Our results show that the characteristic network of lysobisphosphatidic acid-rich membranes contained within multivesicular late endosomes regulates cholesterol transport, presumably by acting as a collection and distribution device. The results also suggest that similar endosomal defects accompany the anti-phospholipid syndrome and NPC.
- Subjects
CHOLESTEROL; ENDOCYTOSIS
- Publication
Nature Cell Biology, 1999, Vol 1, Issue 2, p113
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/10084