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- Title
A functional genetic variation of the 5-HT2a receptor affects human memory.
- Authors
de Quervain, Dominique J-F.; Henke, Katharina; Aerni, Amanda; Coluccia, Daniel; Wollmer, M. Axel; Hock, Christoph; Nitsch, Roger M.; Papassotiropoulos, Andreas
- Abstract
Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.
- Subjects
SEROTONIN; MEMORY; GENETIC polymorphisms
- Publication
Nature Neuroscience, 2003, Vol 6, Issue 11, p1141
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1146