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- Title
The Dynamics of T and B Cells in Lymph Node during Chronic Hiv infection: TFH and Hiv, Unhappy Dance Partners?
- Authors
Jung Joo Hong; Kyu-Tae Chang; Villinger, Francois; Apetrei, Cristian; Pancino, Gianfranco
- Abstract
Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to B cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize what is known regarding the kinetics of TFH cells and GC B cells during the course of infection as well as the potential immunopathological features associated with structural changes in the lymphoid compartment. This review also explores the implications of cell dynamics in the formation and maintenance of viral reservoirs in hyperplastic follicles of secondary lymphoid organs before and after viral suppressive antiretroviral therapy.
- Subjects
HIV infections; THERAPEUTICS; LYMPH nodes; ANTIRETROVIRAL agents
- Publication
Frontiers in Immunology, 2016, Vol 7, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00522