We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of A Novel One-pot Process for the Synthesis of Tolcapone.
- Authors
BODKHE, ARJUN; SUDRIK, VILAS; KARPE, DNYANESHWAR; LAWANDE, SHAMRAO
- Abstract
Novel one-pot process for the preparation of tolcapone., 2-methoxy anisole compound 9 treated with 4-methyl benzoyl chloride compound 10 using aluminium chloride gives 4-hydroxy-3-methoxy-4-methyl benzophenone compound 11 Further on nitration using new nitrating agent i.e. melamine nitrate to get corresponding nitro benzophenone compound 6. After demethylation using 48% HBr-Acetic acid to get pure Tolcapone 1 by the cost-effective and commercially feasible process.
- Subjects
BENZOYL chloride; MELAMINE; ALUMINUM chloride; BENZOYL compounds; HYDROXYBENZOPHENONES; NITRO compounds; BENZOPHENONES; NITRATION
- Publication
Oriental Journal of Chemistry, 2022, Vol 38, Issue 6, p1561
- ISSN
0970-020X
- Publication type
Article
- DOI
10.13005/ojc/380631