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- Title
Concomitant presence of JAK2 V617F mutation and BCR-ABL translocation in a pregnant woman with polycythemia vera.
- Authors
Toogeh, Gholamreza; Ferdowsi, Shirin; Naadali, Fatemeh; Alimoghaddam, Kamran; Ghavamzadeh, Ardeshir; Shirkoohi, Reza; Ghaffari, Seyed
- Abstract
In 2007, a 27-year-old woman presented with mild splenomegaly. Blood counts showed hemoglobin (Hb): 17.8 g/dl, HCT: 56% and Red blood cells: 6.45 × 10/L. Bone marrow examination disclosed a hypercellular marrow. Molecular analysis showed the presence of the JAK2 V617F mutation and BCR-ABL/BCR mRNA b3a2 transcript. A diagnosis of BCR-ABL-positive polycythemia vera (PV) was made. In 2009, she had nulipar pregnancy and treated with interferon-alpha. She delivered a healthy girl infant at 37 weeks. This case report suggests that in a PV pregnant woman with a concomitant presence of JAK2 V617F mutation and BCR-ABL translocation, the administration of interferon during the pregnancy could lead to a safe pregnancy and delivery.
- Subjects
GENETIC mutation; CHROMOSOMAL translocation; GENETICS; PREGNANCY complications; POLYCYTHEMIA
- Publication
Medical Oncology, 2011, Vol 28, Issue 4, p1555
- ISSN
1357-0560
- Publication type
Article
- DOI
10.1007/s12032-010-9570-8