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- Title
A population-based study of gefitinib in patients with non-small cell lung cancer.
- Authors
Kenji Hayashibara; Hiroaki Satoh; Yoko Shinohara; Masaharu Inagaki; Takayuki Kaburagi; Toshio Hashimoto; Koichi Kurishima; Hiroichi Ishikawa; Hideo Ichimura; Takeshi Nawa; Yasunori Funayama; Takeshi Matsumura; Katsunori Kagohashi; Takeshi Endo; Kinya Furukawa; Koji Kishi; Masaaki Sumi; Koichi Kamiyama; Shigemi Ishikawa
- Abstract
Abstract Survival data for non-small cell lung cancer is typically reported from clinical trials that include patients fit enough to meet treatment criteria. The denominator of all patients from which the gefitinib-treated population is derived has rarely been reported and the impact of gefitinib on population-based outcomes is difficult to measure. We have retrospectively reviewed data of 626 patients who received gefitinib in Ibaraki Prefecture (with a population of 3 million) in Japan from July 2002 until September 2007. Overall response rate was found to 30.8%, and the median survival time was 8.0 months (95% confidence interval: 7.0–9.0 months). Female gender, good PS, and adenocarcinoma were significantly associated with prolonged survival. Adverse events were generally mild and were mostly skin reactions and diarrhea. Our population-based study has generated similar results to those previously reported in published clinical trials, which had restrictive criteria for eligible patients.
- Subjects
LUNG cancer; CLINICAL trials; ADENOCARCINOMA; ADVERSE health care events; CANCER patients
- Publication
Medical Oncology, 2009, Vol 26, Issue 2, p222
- ISSN
1357-0560
- Publication type
Article
- DOI
10.1007/s12032-008-9110-y