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- Title
Magnetic FeO-BF: highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles.
- Authors
Shekouhy, Mohsen; Moaddeli, Ali; Khalafi-Nezhad, Ali
- Abstract
FeO magnetic nanoparticle-supported BF was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.
- Subjects
IRON oxide nanoparticles; MAGNETIC nanoparticles; NANOSTRUCTURED materials synthesis; LEWIS acids; ACID catalysts; NITRILE synthesis; CHEMICAL sample preparation; MAGNETIC separation
- Publication
Research on Chemical Intermediates, 2016, Vol 42, Issue 4, p3805
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-015-2246-4