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- Title
Acute fatty liver of pregnancy and neonatal long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency.
- Authors
Gutiérrez Junquera, Carolina; Balmaseda, Elena; Gil, Esther; Martínez, Andrés; Sorli, Moisés; Cuartero, Isabel; Merinero, Begoña; Ugarte, Magdalena
- Abstract
Here we report a 7-month-old girl with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency with hypoketotic hypoglycemia; the mother had a history of acute fatty liver in a previous pregnancy leading to fetal death at 34 weeks of gestation. The misense mutation 1528G > C was detected in both alleles in the proband and in one allele in both parents. We emphasize that screening for fatty acid oxidation disorders and specifically LCHAD deficiency should be performed in newborns from mothers with hepatic complications during pregnancy such as acute fatty liver of pregnancy or severe or recurrent HELLP syndrome.
- Subjects
FATTY liver; INFANT diseases; COENZYMES; DEHYDROGENASES; PREGNANCY complications
- Publication
European Journal of Pediatrics, 2009, Vol 168, Issue 1, p103
- ISSN
0340-6199
- Publication type
Report
- DOI
10.1007/s00431-008-0696-z