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- Title
Induction Chemoradiotherapy Followed by Surgery for Stage III Non-small Cell Lung Cancer.
- Authors
Yoneda, Shuichi; Yamamoto, Mitsunobu; Sakura, Mizuyoshi; Izumo, Toshiyuki; Noguchi, Yukio; Nishimura, Hitoshi; Sakai, Hiroshi; Gotoh, Isao; Kobayashi, Kunihiko; Hayashi, Koichi; Yoshida, Kiyokazu; Hattori, Masao
- Abstract
Twenty-five patients with stage III, non-small cell lung cancer were treated with cisplatin-based chemotherapy and thoracic radiation therapy followed by surgery. Thirteen patients had stage IIIA disease and 12, stage IIIB disease. The chemotherapy and radiotherapy were intensively combined with only a few days' interval between them. Radiation therapy delivering a total dose of 50–70 Gy was started 10 days after the beginning of chemotherapy. A few additional courses of chemotherapy were repeated until a thoracotomy was performed. All but two surgicallytreated patients underwent tumor resection, with 19 lobectomies and four pneumonectomies. Eighteen patients underwent curative and five, non-curative resections. Pathological examination of the resected specimen provided accurate intrathoracic information. Six patients (24%) showed a pathologically complete response, with no cancer cells detected in the resected specimens. Severe postoperative complications occurred in five patients (20%), with one death. The disease recurred in five of the 18 patients who underwent a curative resection. A second primary tumor developed in two other patients. Seventeen patients (68%) are alive, with a median follow-up of 37 months after thoracotomy. The estimated three-year survival was 67% for all patients.
- Publication
Japanese Journal of Clinical Oncology, 1993, Vol 23, Issue 3, p173
- ISSN
0368-2811
- Publication type
Article