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- Title
EVALUATION OF CAUSES OF PANCYTOPENIA ON THE BASIS OF BONE MARROW EXAMINATION AT TERTIARY HEALTH CENTER IN CENTRAL INDIA.
- Authors
PENDRAM, SNEHAL; GEDAM, PALLAVI; PATLE, YOGESH
- Abstract
Introduction: Pancytopenia is reduction in all the three major cellular elements of blood; hence it is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The causes of pancytopenia can be (a) ineffective hematopoiesis with cell death in the marrow, (b) formation of defective cells which are rapidly removed from circulation, (c) sequestration and/or destruction of cells by the action of antibodies or, (d) trapping of normal cells in a hypertrophied and over-reactive reticuloendothelial system.5 The pattern of diseases leading to pancytopenia is expected to vary in different population groups with their difference in age pattern, nutritional status, and prevalence of infective disorders. The severity of pancytopenia and the underlying pathology determines the management and prognosis of these patients. Material & Methods: The present study was carried out in the department of pathology in a tertiary care hospital in central India, from September 2018 to October 2020 from the patients fulfilling the inclusion and exclusion criteria. The cases were selected on the basis of clinical features and laboratory results. Bone marrow aspiration was carried out after getting a written consent from the patient or the guardian. Result: The most common etiology noted was megaloblastic anemia (52%), followed by dimorphic anemia (19%), hypersplenism (10%), leukemia and others.
- Subjects
INDIA; BONE marrow examination; PANCYTOPENIA; MEDICAL centers; BONE marrow; BONE marrow cells; AGE groups
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 3, p1126
- ISSN
0975-3583
- Publication type
Article