We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nonalcoholic Steatohepatitis in Bariatric Patients with a Diagnosis of Obstructive Sleep Apnea.
- Authors
Weingarten, Toby N.; Mantilla, Carlos B.; Swain, James M.; Kendrick, Michael L.; Oberhansley, Jeff M.; Burcham, Robert J.; Ribeiro, Tarsila C.R.; Watt, Kymberly D.; Schroeder, Darrell R.; Narr, Bradly J.; Sprung, Juraj
- Abstract
Objective: To study a possible association between obstructive sleep apnea (OSA) severity, managed with noninvasive ventilation, and nonalcoholic steatohepatitis (NASH) in bariatric surgical patients. Methods: Medical records of 218 bariatric surgical patients who underwent liver biopsy were reviewed. OSA severity was determined from preoperative polysomnography (apnea-hypopnea index (AHI) ≤ 15 no/mild OSA vs. AHI ≥ 16 moderate/severe OSA). Patients diagnosed with OSA were prescribed noninvasive ventilation. Patients were categorized according to liver histopathology into 3 groups: i) no liver disease or simple steatosis, ii) mild NASH (steatosis with necroinflammation and mild fibrosis (stage 0-1)), and iii) advanced NASH (steatosis with necroinflammation and more advanced fibrosis (stage ≥ 2)). Results: 125 patients (57%) had no/mild OSA, and 93 (43%) had moderate/severe OSA. There was no difference in serum aminotransferases between patients by OSA severity classification. There was a high prevalence of hepatic histopathological abnormalities: 84% patients had steatosis, 57% had necroinflammation, 34% had fibrotic changes, and 14% had advanced NASH. There was no association between severity of NASH and severity of OSA. Conclusions: There is no association between stage of steatohepatitis and OSA severity among morbidly obese patients managed with noninvasive ventilation. Copyright © 2012 S. Karger GmbH, Freiburg
- Publication
Obesity Facts: The European Journal of Obesity, 2012, Vol 5, Issue 4, p587
- ISSN
1662-4025
- Publication type
Article
- DOI
10.1159/000342677