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- Title
Carnosine Did Not Affect Vascular and Metabolic Outcomes in Patients with Prediabetes and Type 2 Diabetes: A 14-Week Randomized Controlled Trial.
- Authors
Saadati, Saeede; Cameron, James; Menon, Kirthi; Hodge, Alexander; Lu, Zhong X.; de Courten, Maximilian; Feehan, Jack; de Courten, Barbora
- Abstract
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality in patients with prediabetes and type 2 diabetes mellitus (T2DM). Carnosine has been suggested as a potential approach to reduce ASCVD risk factors. However, there is a paucity of human data. Hence, we performed a 14-week double-blind randomized placebo-controlled trial to determine whether carnosine compared with placebo improves vascular and metabolic outcomes in individuals with prediabetes and T2DM. In total, 49 patients with prediabetes and T2DM with good glycemic control were randomly assigned either to receive 2 g/day carnosine or matching placebo. We evaluated endothelial dysfunction, arterial stiffness, lipid parameters, blood pressure, heart rate, hepatic and renal outcomes before and after the intervention. Carnosine supplementation had no effect on heart rate, peripheral and central blood pressure, endothelial function (logarithm of reactive hyperemia (LnRHI)), arterial stiffness (carotid femoral pulse wave velocity (CF PWV)), lipid parameters, liver fibroscan indicators, liver transient elastography, liver function tests, and renal outcomes compared to placebo. In conclusion, carnosine supplementation did not improve cardiovascular and cardiometabolic risk factors in adults with prediabetes and T2DM with good glycemic control. Therefore, it is improbable that carnosine supplementation would be a viable approach to mitigating the ASCVD risk in these populations. The trial was registered at clinicaltrials.gov (NCT02917928).
- Subjects
AUSTRALIA; CARDIOVASCULAR diseases risk factors; GLOMERULAR filtration rate; ENDOTHELIAL cells; LIVER function tests; OLIGOPEPTIDES; GLYCEMIC control; DISEASES; TYPE 2 diabetes; DIETARY supplements; TREATMENT effectiveness; RANDOMIZED controlled trials; RESEARCH funding; ANALYSIS of covariance; HEART beat; STATISTICAL sampling; BODY mass index; PREDIABETIC state; INSULIN resistance
- Publication
Nutrients, 2023, Vol 15, Issue 22, p4835
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15224835