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- Title
A Probiotic Lactobacillus gasseri Alleviates Escherichia coli -Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota.
- Authors
Yun, Soo-Won; Kim, Jeon-Kyung; Lee, Kyung-Eon; Oh, Young Joon; Choi, Hak-Jong; Han, Myung Joo; Kim, Dong-Hyun
- Abstract
Excessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of Lactobacillus gasseri NK109, which suppressed IL-1β expression in activated macrophages, on Escherichia coli K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1β and populations of NF-κB+/Iba1+ and IL-1R+ cells, and increased the K1-suppressed population of BDNF+/NeuN+ cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1β expression, gut microbiota, and vagus nerve-mediated gut–brain signaling.
- Subjects
PREVENTION of mental depression; INTESTINAL surgery; COLITIS prevention; THERAPEUTIC use of probiotics; ANIMAL experimentation; COGNITION disorders; MENTAL depression; ESCHERICHIA coli diseases; GENE expression; HIPPOCAMPUS (Brain); INTERLEUKIN-1; LACTOBACILLUS; MACROPHAGES; MENTAL illness; MICE; VAGOTOMY; VAGUS nerve; DNA-binding proteins; GUT microbiome; PROBIOTICS; BRAIN-derived neurotrophic factor; DISEASE complications
- Publication
Nutrients, 2020, Vol 12, Issue 11, p3441
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12113441