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- Title
Brain oscillatory responses in bipolar disorder.
- Authors
Özerdem, Ayşegül
- Abstract
Bipolar disorder is a chronic, severe and often debilitating brain illness which is associated with significant cognitive deficits in a number of domains including executive functions, processing speed, attention, memory and social cognition as well as neuroanatomical abnormalities containing neural circuits that regulate cognitive processing. The course of illness is characterized by episodes of mania and depression and well being states (euthymia) between the episodes. Biomarkers for early diagnosis as well as for predicting treatment response are crutial for improving quality of life and longevity in patients suffering from bipolar disorder. Our group focused on oscillatory brain dynamics in bipolar disorder both in euthymic and manic states of illness, with and without medication. Spontaneous, and event related oscillatory activity in the theta, alpha, beta, and gamma frequency ranges as well as long distance coherence in the gamma frequency were assessed in patients in comparison to healthy controls. In drug free patients, during both mania and euthymia, spontaneous and event related alpha activity, event related theta activity and long distance gamma coherence were significantly reduced as opposed to beta range activity which was significantly increased both in mania and euthymia before treatment. Treatment with mood stabilizers seem to cause alterations in oscillatory responses compared to unmedicated state. The findings will be discussed with regard to the corresponding cognitive functioning for the assessed oscillatory activity in different frequency ranges as well as location of the alterations in the oscillatory activity. A proposal for a constellation of oscillatory biomarkers in bipolar disorder will be brought to the attention of the audience.
- Subjects
BIPOLAR disorder; BRAIN stimulation; COGNITION disorders
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2018, Vol 12, Issue Supp1, pS10
- ISSN
1307-8798
- Publication type
Abstract