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- Title
Pathogenesis of Psoriasis: Comparison of Natural Killer Cells, Interleukin-18, Intercellular Adhesion Molecule-1, Interleukin-2-Receptoralpha and sCD44 Status in Patients and Controls.
- Authors
Ghonaim, Mabrouk M.; El-Edel, Rawhia H.; Abo-Salem, Osama M.; Basha, Mohammed A.
- Abstract
Background: Interleukin-18 (IL-18), soluble interleukin-2 receptor-alpha (sIL-2Ra), soluble intercellular adhesion molecule-1 (sICAM-1), soluble CD44 (sCD44) may have a role in psoriasis. Objectives: We aimed to investigate the role of these cytokines, adhesion molecules and soluble receptors in this disease. Patients and Methods: Seventy psoriasis patients and 20 healthy controls were included in this study. Severity of the disease was determined by estimation of psoriasis area severity index (PASI). Serum levels of IL-18, sIL-2Ra, sICAM-1 and sCD44 were determined by enzyme immunoassay. Enumeration of circulating NK cells was performed by flow cytometry. Results: Psoriasis patients had significantly (P<0.001) higher levels of IL-18, sIL-2Ra and sICAM-1 and significantly (P<0.01) lower percentages of NK cells (CD56+, CD56+CD3- and CD56+CD3+) as compared to controls. There were no significant differences in the levels of sCD44. IL-18 was significantly (P<0.01) higher among patients with severe as compared to mild and moderate psoriasis. Levels of sIL-2Ra and sICAM-1 were significantly (P<0.05) higher among patients with severe as compared to mild psoriasis. The percentage of NK-cells and the level of sCD44 were non-significantly related to severity of the disease. There were significant (P<0.01) positive correlations between serum levels of IL-18, sIL-2Ra and sICAM-1. There were also positive correlations (P<0.05) between PASI score and IL-18 and sICAM-1 levels. Conclusion: Increased IL-18 and sICAM-1 levels and their correlation with severity of psoriasis suggest that IL-18 may lead to increased Th1 response and up-regulation of ICAM-1 on monocytes culminating in increased cell infiltration and keratinocyte proliferation. IL-18 and sICAM-1 may serve as useful markers of psoriasis severity and targeting of both cytokines may be useful in treatment of the disease.
- Subjects
PSORIASIS; KILLER cells; INTERLEUKIN-18
- Publication
Ibnosina Journal of Medicine & Biomedical Sciences, 2013, Vol 5, Issue 3, p114
- ISSN
1947-489X
- Publication type
Article
- DOI
10.4103/1947-489x.210534