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- Title
Gout Flare and Cardiovascular Events—Reply.
- Authors
Cipolletta, Edoardo; Tata, Laila J.; Abhishek, Abhishek
- Abstract
Comment & Response B In Reply b Dr Fonseca raises the issue of potential confounding by low-dose aspirin in our study[1] of the association between gout flare and cardiovascular events. If a recent prescription of low-dose aspirin were to elevate serum urate modestly,[[2]] and thereby be associated with gout flares,[4] such prescription should also, by a more direct mechanism, reduce the risk of cardiovascular events.[[5]] Thus, a recent prescription of low-dose aspirin would be more likely to reduce than increase the association between recent prior gout flares and cardiovascular events. Nevertheless, we performed an additional multivariable conditional logistic regression analysis using the fully adjusted model[1] with separate adjustment for current and past low-dose aspirin (tablet strength of <=325 mg) and current and past nonaspirin antiplatelet drug prescriptions.
- Subjects
GOUT
- Publication
JAMA: Journal of the American Medical Association, 2023, Vol 329, Issue 1, p96
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2022.20114