The article discusses a randomized trial which compared cryotherapy and loop electrosurgical excision procedure (LEEP) for the management of cervical cancer in women living with HIV and human papillomavirus (HPV). Topics covered are the risk of cervical intraepithelial neoplasia (CIN), effectiveness of LEEP among women who initiated antiretroviral therapy and LEEP as the preferred treatment for CIN among women living with HIV.