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- Title
Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events.
- Authors
Donadini, Marco P.; Bellesini, Marta; Squizzato, Alessandro
- Abstract
<bold>Clinical Question: </bold>Among patients at high risk for or with established cardiovascular disease (ie, history of peripheral artery disease, stroke, or coronary artery disease without a coronary stent), is the addition of clopidogrel to aspirin associated with lower risk of mortality and cardiovascular events compared with aspirin alone?<bold>Bottom Line: </bold>Clopidogrel plus aspirin is associated with a reduced risk for myocardial infarction and ischemic stroke and an increased risk for major bleeding compared with aspirin alone among patients at high risk for or with an established cardiovascular disease but without a coronary stent. However, combined therapy is not associated with lower mortality.
- Subjects
ASPIRIN; CLOPIDOGREL; CARDIOVASCULAR diseases; CARDIOVASCULAR system; CARDIOVASCULAR agents
- Publication
JAMA: Journal of the American Medical Association, 2018, Vol 320, Issue 6, p593
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.2018.9641