We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tau and neurodegenerative disorders.
- Authors
Motoi, Yumiko; Sahara, Naruhiko; Kambe, Taiki; Hattori, Nobutaka
- Abstract
The mechanisms that render tau a toxic agent are still unclear, although increasing evidence supports the assertion that alterations of tau can directly cause neuronal degeneration. In addition, it is unclear whether neurodegeneration in various tauopathies occurs via a common mechanism or that specific differences exist. The aim of this review is to provide an overview of tauopathies from bench to bedside. The review begins with clinicopathological findings of familial and sporadic tauopathies. It includes a discussion of the similarities and differences between these two conditions. The second part concentrates on biochemical alterations of tau such as phosphorylation, truncation and acetylation. Although pathological phosphorylation of tau has been studied for many years, recently researchers have focused on the physiological role of tau during development. Finally, the review contains a summary of the significance of tauopathy model mice for research on neurofibrillary tangles, axonopathies, and synaptic alteration.
- Subjects
NEURODEGENERATION; POISONS; MICROTUBULES; PHOSPHORYLATION; ACETYLATION; BIOCHEMICAL toxicology; FRONTOTEMPORAL dementia; PROGRESSIVE supranuclear palsy; TRANSGENIC mice
- Publication
Biomolecular Concepts, 2010, Vol 1, Issue 2, p131
- ISSN
1868-5021
- Publication type
Article
- DOI
10.1515/BMC.2010.017