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- Title
Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant.
- Authors
Neugut, Y. Dana; Mohan, Sumit; Gharavi, Ali G.; Kiryluk, Krzysztof
- Abstract
This article discusses potential indications for genetic testing in an African American patient with chronic kidney disease who is being evaluated for a kidney transplant. Two known risk variants in the APOL1 (apolipoprotein L1) gene predispose to kidney disease and are found almost exclusively in persons of African ancestry. APOL1 risk variants are considered, including whether clinicians should incorporate genetic testing in the screening process for living kidney donors. In addition to APOL1 testing, the role of diagnostic exome sequencing in evaluating potential transplant recipients and donors with a positive family history of kidney disease is discussed.
- Subjects
CHRONIC kidney failure; GENETIC testing; INDIVIDUALIZED medicine; ORGAN donor registries; KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; APOLIPOPROTEIN E4
- Publication
Annals of Internal Medicine, 2019, Vol 171, Issue 9, p659
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/M19-1389