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- Title
Chemical Intervention on Staphylococcus aureus Virulence.
- Authors
Zhou, Lin‐Lin; Yang, Cai‐Guang
- Abstract
Resistance to conventional antibiotics has raised worldwide attention. Notably, Methicillin‐resistant Staphylococcus aureus (MRSA) has become one of the most life‐threatening health concerns. Although effective against bacterial infections, conventional antibiotics have also showed a series of side effects such as gut microbiota imbalance. An alternative is in urgent need in order to combat bacterial infections. Antivirulence represents a new approach to circumvent these shortcomings, which focuses on disarming the "weapons" for pathogenicity without much selective pressure on bacterial survival. In this review, we place emphasis on the chemical modulation of biosynthesis, assembly, function and the regulation of some major virulence factors in S. aureus, which we hope will help the development of antivirulence modulators. Virulence factors of S. aureus become a new approach to combat bacterial infections and circumvent the shortcomings of conventional antibiotics. In this review, we place emphasis on the chemical modulation of some major virulence factors in S. aureus.
- Subjects
STAPHYLOCOCCUS aureus; ANTIBIOTICS; METHICILLIN resistance; BACTERIAL diseases; BIOSYNTHESIS
- Publication
Chinese Journal of Chemistry, 2019, Vol 37, Issue 2, p183
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.201800470