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- Title
Sdhd and Sdhd/H19 Knockout Mice Do Not Develop Paraganglioma or Pheochromocytoma.
- Abstract
The article focuses on the succinate dehydrogenase, subunit D (SDHD) and Sdhd/H19 knockout mice related to paraganglioma or pheochromocytoma. It mentions that the SDH is the part of tricarboxylic acid cycle and the electron transport chain. It mentions that the mutations of SDHD lead to head and neck paragangliomas (HN-PGL), related to carotid body and other parasympathetically innervated paraganglia. It mentions that the SDHD is a human tumor suppressor gene, heterozygous missense and nonsense mutations with the loss of heterozygosity (LOH).
- Subjects
SUCCINATE dehydrogenase; LABORATORY mice; PARAGANGLIOMA; PHEOCHROMOCYTOMA; KREBS cycle; ELECTRON transport; CAROTID body; NONCHROMAFFIN paraganglia; HETEROZYGOSITY
- Publication
PLoS ONE, 2009, Vol 4, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0007987