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- Title
Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.
- Authors
Mastroianno, Sandra; Di Stolfo, Giuseppe; Seripa, Davide; Pacilli, Michele Antonio; Paroni, Giulia; Coli, Carlo; Urbano, Maria; d’Arienzo, Carmela; Gravina, Carolina; Potenza, Domenico Rosario; De Luca, Giovanni; Greco, Antonio; Russo, Aldo
- Abstract
Background: Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis. Objectives: To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease. Materials and methods: 258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion. Results: As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripheral revascularization (22.64% vs. 5.06%; p < 0.001) was observed. Prospective analysis, showed that ε4-carriers have an increased hazard ratio for major adverse cardiovascular events (adjusted HR 1.829, 95% CI 1.017–3.287; p = 0.044) and total peripheral revascularization (adjusted HR = 5.916, 95% CI 2.405–14.554, p <0.001). Conclusions: The ε4 allele seems to be risk factor for major adverse cardiovascular events, and in particular for total peripheral revascularization in patients with advanced atherosclerotic vascular disease.
- Subjects
APOENZYMES; GENETIC polymorphisms; CAROTID artery; REVASCULARIZATION (Surgery); ARM surgery
- Publication
PLoS ONE, 2017, Vol 12, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0171055