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- Title
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster.
- Authors
BANDARRA, Daniel; BIDDLESTONE, John; MUDIE, Sharon; MULLER, H. Arno; ROCHA, Sonia
- Abstract
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival. In mammalian cells, hypoxia not only activates the HIF (hypoxia-inducible factor) family, but also additional transcription factors such as NF-κB (nuclear factor κB). Here we show that hypoxia activates the IKK-NF-κB [IκB (inhibitor of nuclear factor κB)-NF-κB] pathway and the immune response in Drosophila melanogaster. We show that NF-κB activation is required for organism survival in hypoxia. Finally, we identify a role for the tumour suppressor Cyld, as a negative regulator of NF-κB in response to hypoxia in Drosophila. The results indicate that hypoxia activation of the IKK-NF-κB pathway and the immune response is an important and evolutionary conserved response.
- Subjects
PATHOPHYSIOLOGY of anoxemia; HYPOXIA-inducible factor 1; DROSOPHILA melanogaster; IKAPPA B kinase; NF-kappa B; IMMUNE response; PHYSIOLOGY; INSECTS
- Publication
Bioscience Reports, 2014, Vol 34, Issue 4, p429
- ISSN
0144-8463
- Publication type
Article
- DOI
10.1042/BSR20140095