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- Title
Alterations in peripheral T‐ and B‐cell subsets in patients with systemic sclerosis.
- Authors
Wu, Jialing; Zhang, Xi; Lin, Shen; Wei, Qiujing; Lin, Zhiming; Jin, Ou; Gu, Jieruo
- Abstract
Objectives: To determine the alteration of peripheral T and B cell subsets in patients with systemic sclerosis (SSc) and to evaluate their correlation with the progression of SSc. Methods: We recruited 47 SSc patients and 45 healthy controls (HCs) in this study. Demographic and clinical data were then collected. Flow cytometry was used to detect the proportions of 44 different T and B cell subsets in circulating blood. Results: The proportion of total B cells (p =.043) decreased in SSc patients, together with similar frequencies of total T cells, CD4+ T cells, and CD8+ T cells in both groups. Several subsets of T and B cells differed significantly between these two groups. Follicular helper T cells‐1 (Tfh1) (p <.001), helper T cells‐1 (Th1) (p =.001), regulatory T cells (Treg) (p =.004), effector memory CD8+ T cells (p =.041), and cytotoxic T cells‐17 (Tc17) (p =.01) were decreased in SSc patients. Follicular helper T cells‐2 (Tfh2) (p =.001) and, helper T cells‐2 (Th2) (p =.001) levels increased in the SSc group. Regulatory B cells (Breg) (p =.015) were lower in the SSc group, together with marginal zone (MZ) B cells (p <.001), memory B cells (p =.001), and non‐switched B cells (p =.005). The modified Rodnan skin score (mRSS) correlated with helper T cells‐17 (Th17) (r = −.410, p =.004), Tfh1 (r = −.321, p =.028), peripheral helper T cells (Tph) (r = −.364, p =.012) and plasma cells (r = −.312, p =.033). Conclusions: The alterations in T and B cells implied immune dysfunction, which may play an essential role in systemic sclerosis.
- Subjects
REGULATORY B cells; SYSTEMIC scleroderma; T helper cells; REGULATORY T cells; T cells
- Publication
International Journal of Rheumatic Diseases, 2024, Vol 27, Issue 4, p1
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.15145