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- Title
The Clinical Course and Prognostic Factors of COVID-19 in Patients with Chronic Kidney Disease, A Study in Six Centers.
- Authors
Najafi, Neda; Akbari, Roghayeh; Lotfi, Zahra; Makhlough, Atieh; Vahedi, Mohsen; Asgharpour, Masoumeh; Sabagh, Mahin Ghorban; Marghoob, Bahareh; Ilali, Narges Mirzaei; Saddadi, Fereshteh; Shams, Zahra; Ossareh, Shahrzad; Makhough, Atieh; Ghorban Sabagh, Mahin; Mirzaei Ilali, Narges; Ossareh, Sharzad
- Abstract
<bold>Introduction: </bold>Coronavirus disease 19 (COVID-19), has recently emerged as a great health challenge. The novel corona virus may affect the kidneys mainly as acute kidney injury (AKI). Also, the outcome of COVID-19 may be different in patients with underlying kidney disease. The aim of this study was to compare the outcome of COVID-19 in patients with and without underlying kidney disease.<bold>Methods: </bold>This was a retrospective study on 659 hospitalized COVID-19 patients in six centers of Iran. Patients were classified into kidney (chronic kidney disease (CKD), end-stage kidney disease (ESKD) or kidney transplantation) and non-kidney groups. The clinical conditions and laboratory data were extracted from the charts. Outcome was defined as death during hospitalization or within 30 days of discharge.<bold>Results: </bold>Among 659 COVID-19 patients (mean age: 60.7 ± 16.4, 56% male), 208 were in the kidney group (86 ESKD, 35 kidney transplants, and 87 CKD patients). AKI occurred in 41.8%. Incidence of AKI was 34.7% in non-kidney, 74.7% in CKD, and 51.4% in kidney transplant patients (P < .001). Totally 178 patients (27%) died and mortality rate was significantly higher in CKD patients (50.6 vs. 23.4%, P < .001). AKI was associated with increased mortality rate (OR = 2.588, CI: 1.707 to 3.925). Initial glomerular filtration rate (GFR) < 44.2 mL/min and elevated lactate dehydrogenase (LDH) and C-reactive protein (CRP) had significant association with mortality.<bold>Conclusion: </bold>We showed a higher mortality rate in COVID-19 patients with AKI and CKD. Low initial GFR and elevated LDH and CRP were associated with high mortality in COVID-19 patients.
- Subjects
IRAN; COVID-19; CHRONIC kidney failure; PROGNOSIS; ACUTE kidney failure
- Publication
Iranian Journal of Kidney Diseases, 2021, Vol 15, Issue 4, p279
- ISSN
1735-8582
- Publication type
journal article