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- Title
COMPARATIVE CYTOTOXICITY ASSAYS PERFORMED USING A FREE PORPHYRIN AND ITS Zn(II), Co(II) AND Cu(II) COMPLEXES. INFLUENCE OF OPTICAL AND AGGREGATION PROPERTIES.
- Authors
ALEXANDROVA, RADOSTINA; KALFIN, RENI; TUDOSE, RAMONA; FAGADAR-COSMA, EUGENIA
- Abstract
Our present approach is dealing with comparative cytotoxicity assays performed with a porphyrin base, substituted with methoxy-inductive donor substituents in the meso position, namely: 5,10,15,20-tetrakis-(pmethoxy- phenyl porphyrin (TMeOPP) and with its Zn(II), Co(II) and Cu(II) complexes (Figure 1). The cytotoxicity evaluation was performed using human (HeLa, 8 MGBA, Lep-3) and bovine (MDBK) cell lines as model systems. The influence of the compounds on cell viability and proliferation was studied by (thiazolyl blue tetrazolium bromide) MTT test and further discussed taking into consideration the main optical and aggregation properties of the free porphyrin and its different metal complexes.
- Subjects
CELL-mediated cytotoxicity; PORPHYRINS; CELL lines; CELL proliferation; TETRAZOLIUM compounds
- Publication
Studia Universitatis Babes-Bolyai, Chemia, 2018, Vol 63, Issue 4, p65
- ISSN
1224-7154
- Publication type
Article
- DOI
10.24193/subbchem.2018.4.05