We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical constituents of Desmodium triflorum and their antifungal activity against various phytopathogenic fungi.
- Authors
Nguyen-Ngoc, Hieu; Nguyen-Thi-Thu, Trang; Vo-Thi, Kieu-Anh; Nguyen-Huu, Tung; Tran-Dai, Lam; Vu, Hoang Dinh; Nghiem, Duc Trong; Le Dang, Quang
- Abstract
In the course of finding new antifungal natural compounds against plant pathogens, the methanol extract of Desmodium triflorum was investigated phytochemically. From n-butanol-soluble fraction, seven compounds (1–7) were isolated and structurally elucidated. Of which, six compounds belong to flavone 6- or 8-C-glycoside class (1–6). Three major compounds (1–3) exhibited moderate in vitro antifungal activity against Sclerotium rolfsii, Fusarium oxysporum f. sp. cubense, and Phytophthora palmivora. Compound 1 (IC50 = 162.1 μg/mL) was most active against S. rolfsii in a dose-dependent manner. At 300 μg/mL, compounds 1 and 2 significantly inhibited P. palmivora, whereas compound 3 lacked effectiveness. In addition, the nanoemulsion of the methanol extract with a droplet size of 12.2 nm displayed an excellent inhibition against S. rolfsii and P. palmivora compared with the normal extract. The presence of 1 (0.846%) and 2 (0.759%) in the methanol extract may attribute to the antifungal activity of D. triflorum. These results proved the potential of D. triflorum and its C-glycoside flavonoids against phytopathogenic fungi for the first time. Besides, an enhancement in the effectiveness of nanoemulsion containing D. triflorum extract against the fungi was confirmed. The structural characteristics of 1 and 2 could be considered to develop new fungicidal substances in the future.
- Subjects
PHYTOPATHOGENIC fungi; DESMODIUM; SCLEROTIUM rolfsii; ANTIFUNGAL agents; PHYTOPATHOGENIC microorganisms; FUSARIUM oxysporum; FLAVONOID glycosides
- Publication
Zeitschrift für Naturforschung. Section C: A Journal of Biosciences, 2023, Vol 78, Issue 5/6, p179
- ISSN
0939-5075
- Publication type
Article
- DOI
10.1515/znc-2022-0048