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- Title
Sialidase inhibitors DAMPen sepsis.
- Authors
Paulson, James C.; Kawasaki, Norihito
- Abstract
The article discusses a study about the role of sialidase inhibitors in ameliorating sepsis. It notes that the inflammatory response to intestinal sepsis tends to be aggravated by bacterial sialidases. Toll-like receptor (TLR) signaling by the so-called danger-associated molecular patterns (DAMPs) that can exacerbate sepsis has been found to be suppressible by an inhibitory circuit. Results of the study show that mice that are deficient in either the SiglecG or CD24 inhibitors have exhibited an increase in mortality and inflammatory cytokine production.
- Subjects
NEURAMINIDASE; SEPTICEMIA treatment; LABORATORY mice; CYTOKINES; MORTALITY; THERAPEUTICS
- Publication
Nature Biotechnology, 2011, Vol 29, Issue 5, p406
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt.1859