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- Title
Tribuli fructus constituents protect against tacrine-induced cytotoxicity in HepG2 cells.
- Authors
Byun, Erisa; Jeong, Gil-Saeng; An, Ren-Bo; Min, Tae; Kim, Youn-Chul
- Abstract
A new phenolic amide, tribulusimide D (4-hydroxy- N-[3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-methoxybenzamide) ( 1), together with a known phenolic amide, terrestriamide (( E)-3-(4-hydroxy-3-methoxyphenyl)- N-[2-(4-hydroxyphenyl)-2-oxoethyl]-prop-2-enamide) ( 2) and a flavonol glycoside, quercetin-3- O-β- d-glucopyranosyl-(1→6)-β- d-glucopyranoside ( 3) were isolated from the H2O extract of Tribuli Fructus. Compounds 1 and 3 showed significant hepatoprotective activities, with EC50 values of 13.46 ± 0.2 and 7.06 ± 0.7 μM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
- Publication
Archives of Pharmacal Research, 2010, Vol 33, Issue 1, p67
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-010-2226-6