We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line.
- Authors
Huang, Jian; Tang, Xiao-hui; Ikejima, Takashi; Sun, Xiu-jia; Wang, Xiao-bo; Xi, Rong-gang; Wu, Li-jun
- Abstract
A new triterpenoid, 20( R),22( ξ),24( S)-dammar-25(26)-ene-3 β,6 α,12 β,20,22,24-hexanol ( 1), and three known triterpenoids, β-D-glucopyranoside,(3 β,12 β)-12,20-dihydroxydammar-24-en-3-yl,6-acetate ( 2), 20( R)-ginsenoside Rg3 ( 3), and 20( R)-ginsenoside Rh2 ( 4), were isolated from the leaves of Panax ginseng. Their structures were determined by chemical analysis and spectral methods (IR, 1D and 2D NMR, HR-ESI-MS). Compounds 1–4 were exhibited various degrees of cytotoxicity in the human hepatoma cell line, HepG2. Compound 1 had the highest cytotoxic potency, with an IC50 value of 20.1 μM, by stimulating p53-mediated cell cycle arrest at the G1 to S phase transition, leading to apoptosis via activation of the caspase signaling pathway.
- Publication
Archives of Pharmacal Research, 2008, Vol 31, Issue 3, p323
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-001-1159-8