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- Title
Submandibular salivary gland transfer for the prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma: 5-Year outcomes.
- Authors
Xue-Kui Liu; Yong Su; Jha, Naresh; Ming-Huan Hong; Hai-Qiang Mai; Wei Fan; Zong-Yuan Zeng; Zhu-Ming Guo
- Abstract
Background. Our aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma (NPC). Methods. In all, there were 70 patients, consisting of a test group (36 patients) and a control group (34 patients) in a nonrandomized fashion. In the test group, the submandibular salivary gland was transferred to submental space before radiotherapy (XRT) and shielded. Salivary gland functions were evaluated by the amount of saliva and a quality of life questionnaire before and after XRT and 3 and 60 months after XRT. Results. At 5 years, the trapping and excretion functions of salivary gland were significantly better in the test group (p = .000 and p = .000). The mean weight of saliva after XRT was heavier (1.65 g vs 0.73 g, p = .000), and the incidence of xerostomia was lower in the test group, with no difference in 5-year survival and neck nodal recurrence between the 2 groups. Conclusions. Salivary gland transfer procedure prevents XRT-induced xerostomia and improves quality of life of patients with NPC.
- Subjects
SUBMANDIBULAR gland; NASOPHARYNX cancer patients; QUALITY of life; CLINICAL trials; RADIOTHERAPY; VISUAL analog scale; SURGERY
- Publication
Head & Neck, 2011, Vol 33, Issue 3, p389
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21461