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- Title
Renal kallikrein-kinin system.
- Authors
Scicli, A. Guillermo; Carretero, Oscar A.
- Abstract
Although the primary function of the kidney is regulation of the volume and ionic composition of body fluids, it is also an endocrine organ with an important role in the regulation of blood pressure. Some renal hormones have both vasoconstrictor and antinatriuretic effects (vasopressor systems) while others have vasodilator and natriuretic effects (vasodepressor systems). A characteristic of these systems is that they act not only on distant target organs but also in the kidney itself (local hormones or autacoids). For example, the renin-angiotensin, prostaglandin, and kallikrein-kinin systems, whose activation and actions appear to be interrelated, may participate in the control of blood pressure not only by altering the tone of extrarenal blood vessels, but also by directly regulating intrarenal sodium and water excretion, perhaps by regulating renal blood flow distribution. The renal kallikrein-kinin system is the least well defined of these systems, yet it has been implicated in the control of renal blood flow and function, in the pathogenesis of hypertension. Banter syndrome, and renal diseases, and in the antihypertensive mechanism of drugs such as diuretics and angiotensin I converting enzyme inhibitors. However, the unequivocal role of the renal kallikrein-kinin system in these normal and pathological conditions still remains unknown.
- Subjects
KALLIKREIN; KININS; HYPERTENSION; REGULATION of blood pressure; PATHOLOGY; NEPHROLOGY
- Publication
Kidney International, 1986, Vol 29, Issue 1, p120
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1986.14