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- Title
Upper Gastrointestinal Function in Morbidly Obese Adolescents Before and 6 Months After Gastric Banding.
- Authors
Singendonk, M.; Kritas, S.; McCall, L.; Ferris, L.; Omari, T.; Feinle-Bisset, C.; Frisby, C. L.; Kentish, S. J.; Page, A. J.; Kow, L.; Chisholm, J.; Khurana, S.
- Abstract
Background: The effects of laparoscopic adjustable gastric band (LAGB) placement on upper gastrointestinal tract function in obese adolescents are unknown. Therefore, our aim was to determine the short-term effects of LAGB on esophageal motility, gastroesophageal reflux, gastric emptying, appetite-regulatory hormones, and perceptions of post-prandial hunger and fullness.Methods: This study was part of a prospective cohort study (March 2009-December 2015) in one tertiary referral hospital. The study included obese adolescents (14-18 years) with a body mass index (BMI) > 40 (or ≥ 35 with comorbidities). Gastric emptying was assessed by 13C-octanoic acid breath test, pharyngeal, and esophageal motor function by high-resolution manometry with impedance (HRIM), and appetite and other perceptions using 100-mm visual analogue scales. Dysphagia symptoms were scored using a Dakkak questionnaire. Data were compared pre- and post-LAGB placement and at a 6-month follow-up.Results: Based upon analysis of 15 adolescents, at the 6-month follow-up, LAGB placement: (i) led to a significant reduction in weight and BMI; (ii) increased fullness and decreased hunger post-meal; (iii) increased symptoms of dysphagia after solid food; and, despite these effects, (iv) caused little or no changes to appetite hormones, while (v) effects on gastric emptying, esophageal motility, esophageal bolus transport, and esophageal emptying were not significant.Conclusion: In adolescents, LAGB improved BMI and altered the sensitivity to nutrients without significant effects on upper gastrointestinal tract physiology at the 6-month follow-up.
- Subjects
GASTROINTESTINAL motility; ADOLESCENT obesity; GASTRIC banding; BODY mass index; ESOPHAGOGASTRIC junction diseases
- Publication
Obesity Surgery, 2018, Vol 28, Issue 5, p1277
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-017-3000-3