We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders.
- Authors
Machhi, Jatin; Kevadiya, Bhavesh D.; Muhammad, Ijaz Khan; Herskovitz, Jonathan; Olson, Katherine E.; Mosley, R. Lee; Gendelman, Howard E.
- Abstract
Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory neuroprotective regulatory T cells (Tregs). An imbalance between Teffs and Tregs leads to microglial activation, inflammation and neuronal injury. The cascade of such a disordered immunity includes the drainage of the aggregated protein antigens into cervical lymph nodes serving to amplify effector immune responses. Both preclinical and clinical studies demonstrate transformation of this altered immunity for therapeutic gain. We posit that the signs and symptoms of common neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke can be attenuated by boosting Treg activities.
- Subjects
SUPPRESSOR cells; NEURODEGENERATION; AMYOTROPHIC lateral sclerosis; T cells; IMMUNE response; ENDOPLASMIC reticulum; NEUROGLIA
- Publication
Molecular Neurodegeneration, 2020, Vol 15, Issue 1, p1
- ISSN
1750-1326
- Publication type
Article
- DOI
10.1186/s13024-020-00375-7