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- Title
Atividade Antifúngica In Vitro do Extrato da Uncaria Tomentosa L. (Unha De Gato) sobre Cepas do Gênero Candida.
- Authors
Júnior, Umberto Pereira Souza; Pereira, Jozinete Vieira; Pereira, Maria Socorro Vieira; Costa, Maria Regina Macedo; Pereira, Andréia Vieira; Antunnes, Rossana Miranda Pessoa
- Abstract
Objective: The aim of this study was to evaluate in vitro the antifungal effect of the hydroalcoholic extract of Uncaria tomentosa L. (Cat's Claw) on strains of Candida albicans ATCC 36232, Candida guilliermondii ATCC 6260, Candida krusei ATCC 34135 and Candida tropicalis ATCC 13 803, responsible for oral diseases known as candidiasis or candioses. Methods: The botanical material used in the tests were sputtered from the stem of Uncaria tomentosa L., which was then subjected to the maceration process for preparing the extract. We used standardized strains of Candida microorganisms (ATCC), obtained upon request at the Oswaldo Cruz Foundation, Rio de Janeiro. The antimicrobial activity and determination of Minimum Inhibitory Concentration (MIC) of the extract of Uncaria tomentosa L. was determined by agar-diffusion technique in Petri dishes, solid Mueller Hinton Agar - DIFCO. The same procedures were performed with the 0.12% chlorhexidine, an antiseptic used as positive control in the experiments. Results: All species evaluated were sensitive to the extract of Uncaria tomentosa L., operating similarly to the action of chlorhexidine (positive control). The strains showed inhibition zones of growth until the 1:16 dilution of the extract. Candida albicans was the microorganism that showed greater sensitivity to the extract of Uncaria tomentosa L., followed by Candida guilliermondii, Candida krusei and Candida tropicalis. Conclusion: The results of this study show that Uncaria tomentosa L., popularly known as cat's claw, has bioactive compounds with antimicrobial activity against fungi of the genus Candida are responsible for the manifestations of oral candidiasis.
- Subjects
ANTIFUNGAL agents; UNCARIA tomentosa; CANDIDA; PLANT extracts; MICROORGANISMS; BIOACTIVE compounds; MEDICAL botany
- Publication
Pesquisa Brasileira em Odontopediatria e Clinica Integrada, 2011, Vol 11, Issue 4, p477
- ISSN
1519-0501
- Publication type
Article
- DOI
10.4034/PBOCI.2011.114.03