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- Title
Negative association between Catechol- O-methyltransferase ( COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia.
- Authors
Lai, I.-C.; Wang, Y.-C.; Lin, C.-C.; Bai, Y.-M.; Liao, D.-L.; Yu, S.-C.; Lin, C.-Y.; Chen, J.-Y.; Liou, Y.-J.
- Abstract
Chronic administration of typical antipsychotic agents, which mainly act on the dopamine receptors, implicates a role of dopamine system on the susceptibility of tardive dyskinesia (TD). In the present study, the association between a functional Val158Met polymorphism of Catechol- O-methyltransferase ( COMT) gene and TD occurrence and TD severity was investigated in 299 Chinese schizophrenic patients with long-term antipsychotic treatment (TD: 166, non-TD: 133). After adjusting the effects of confounding factors, there was no significant association between COMT genotype and TD occurrence (p=0.367). Among TD patients, we found no significant correlation between COMT genotypes and the total scores of abnormal involuntary movement scale (AIMS) (p=0.629). We concluded that this COMT polymorphism might not play a major role in the susceptibility of TD nor on the severity of TD.
- Subjects
SCHIZOPHRENIA; TARDIVE dyskinesia; GENETIC polymorphisms; POPULATION genetics; EFFECT of drugs on basal ganglia; SIDE effects of psychiatric drugs
- Publication
Journal of Neural Transmission, 2005, Vol 112, Issue 8, p1107
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-004-0252-6