We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Localised astroglial dysfunction disrupts high-frequency EEG rhythms.
- Authors
Willoughby, J. O.; Mackenzie, L.; Pope, K. J.; Broberg, M.; Nilsson, M.
- Abstract
We used cerebral cortex injections of fluorocitrate to determine if selective astrocytic disturbances affect the electroencephalogram (EEG). Rats were halothane-anaesthetized and 0.8?nmol of sodium fluorocitrate was injected into hindlimb (motor-sensory) cortex. Extra-dural EEG electrodes were implanted after which the anaesthesia was ceased. EEG was recorded at 1, 3, 5, 7, 24 and 48 hours. There was a broad-band reduction in frequencies in the EEG between 20 and 100?Hz commencing within 1 hour of injection and largely restricted to the side of injection and to frontal cortex, and maximal at 3 hours. Halothane had a suppressive effect on gamma power after citrate injection, but also prevented EEG suppression caused by fluorocitrate, consistent with the hypothesis that some of the action of fluorocitrate depended on gap-junctions. The findings are consistent with the hypothesis that primary astroglial dysfunction leads to reduced neuronal transmission and further supports gap-junctions as mediating fluorocitrate-induced astroglial effects.
- Subjects
ELECTROENCEPHALOGRAPHY; SODIUM compounds; ANESTHETICS; HALOTHANE; CEREBRAL cortex; DIAGNOSIS of brain diseases
- Publication
Journal of Neural Transmission, 2005, Vol 112, Issue 2, p205
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-004-0189-9