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- Title
The effect of blood‐flow‐restricted interval training on lactate and H<sup>+</sup> dynamics during dynamic exercise in man.
- Authors
Christiansen, Danny; Eibye, Kasper; Hostrup, Morten; Bangsbo, Jens
- Abstract
Aim: To assess how blood‐flow‐restricted (BFR) interval‐training affects the capacity of the leg muscles for pH regulation during dynamic exercise in physically trained men. Methods: Ten men (age: 25 ± 4y; V˙O2max: 50 ± 5 mL∙kg−1∙min−1) completed a 6‐wk interval‐cycling intervention (INT) with one leg under BFR (BFR‐leg; ~180 mmHg) and the other without BFR (CON‐leg). Before and after INT, thigh net H+‐release (lactate‐dependent, lactate‐independent and sum) and blood acid/base variables were measured during knee‐extensor exercise at 25% (Ex25) and 90% (Ex90) of incremental peak power output. A muscle biopsy was collected before and after Ex90 to determine pH, lactate and density of H+‐transport/buffering systems. Results: After INT, net H+ release (BFR‐leg: 15 ± 2; CON‐leg: 13 ± 3; mmol·min−1; Mean ± 95% CI), net lactate‐independent H+ release (BFR‐leg: 8 ± 1; CON‐leg: 4 ± 1; mmol·min−1) and net lactate‐dependent H+ release (BFR‐leg: 9 ± 3; CON‐leg: 10 ± 3; mmol·min−1) were similar between legs during Ex90 (P >.05), despite a ~142% lower muscle intracellular‐to‐interstitial lactate gradient in BFR‐leg (−3 ± 4 vs 6 ± 6 mmol·L−1; P <.05). In recovery from Ex90, net lactate‐dependent H+ efflux decreased in BFR‐leg with INT (P <.05 vs CON‐leg) owing to lowered muscle lactate production (~58% vs CON‐leg, P <.05). Net H+ gradient was not different between legs (~19%, P >.05; BFR‐leg: 48 ± 30; CON‐leg: 44 ± 23; mmol·L−1). In BFR‐leg, NHE1 density was higher than in CON‐leg (~45%; P <.05) and correlated with total‐net H+‐release (r = 0.71; P =.031) and lactate‐independent H+ release (r = 0.74; P =.023) after INT, where arterial [HCO3‐] and standard base excess in Ex25 were higher in BFR‐leg than CON‐leg. Conclusion: Compared to a training control, BFR‐interval training increases the capacity for pH regulation during dynamic exercise mainly via enhancement of muscle lactate‐dependent H+‐transport function and blood H+‐buffering capacity.
- Subjects
INTERVAL training; LEG muscles; LACTATES
- Publication
Acta Physiologica, 2021, Vol 231, Issue 3, p1
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/apha.13580