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- Title
Dynamics of Anti-influenza Mucosal IgA Over a Season in a Cohort of Individuals Living or Working in a Long-term Care Facility.
- Authors
Hitchings, Matt D T; Borgert, Brooke A; Shir, Adam; Yang, Bingyi; Grantz, Kyra H; Ball, Jacob; Moreno, Carlos A; Rand, Kenneth; Small, Parker A; Fowke, Keith R; Cummings, Derek A T
- Abstract
Background Serological surveys are used to ascertain influenza infection and immunity, but evidence for the utility of mucosal immunoglobulin A (IgA) as a correlate of infection or protection is limited. Methods We performed influenza-like illness (ILI) surveillance on 220 individuals living or working in a retirement community in Gainesville, Florida from January to May 2018, and took pre- and postseason nasal samples of 11 individuals with polymerase chain reaction (PCR)-confirmed influenza infection and 60 randomly selected controls. Mucosal IgA against 10 strains of influenza was measured from nasal samples. Results Overall, 28.2% and 11.3% of individuals experienced a 2-fold and 4-fold rise, respectively, in mucosal IgA to at least 1 influenza strain. Individuals with PCR-confirmed influenza A had significantly lower levels of preseason IgA to influenza A. Influenza-associated respiratory illness was associated with a higher rise in mucosal IgA to influenza strains of the same subtype, and H3N2-associated respiratory illness was associated with a higher rise in mucosal IgA to other influenza A strains. Conclusions By comparing individuals with and without influenza illness, we demonstrated that mucosal IgA is a correlate of influenza infection. There was evidence for cross-reactivity in mucosal IgA across influenza A subtypes.
- Subjects
GAINESVILLE (Fla.); LONG-term care facilities; RETIREMENT communities; POLYMERASE chain reaction; INFLUENZA
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 4, p383
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad029