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- Title
Aluminum exposure through parenteral nutrition formulations: Mathematical versus clinical relevance.
- Authors
Canada, Todd W.
- Abstract
The article reports that aluminum exposure from parenteral nutrition (PN) formulations was first associated with osteomalacia some 25 years ago. Aluminum contamination in these formulations impaired normal osteoblast proliferation and calcium uptake by bone, thereby contributing to adynamic bone disease. The U.S. Food & Drug Administration (FDA) mandate for labeling aluminum content in PN formulations took effect on July 26, 2004. Manufacturers are required to report their maximum level of aluminum at expiration for large- and small-volume additives used in PN preparation. This may concern many pharmacists, since the aluminum concentration reported for U.S. products varies depending on the salt, the container, and the manufacturer.
- Subjects
UNITED States; ALUMINUM; PARENTERAL feeding; UNITED States. Food &; Drug Administration; BONE diseases; PHARMACISTS
- Publication
American Journal of Health-System Pharmacy, 2005, Vol 62, Issue 3, p315
- ISSN
1079-2082
- Publication type
Article