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- Title
Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG).
- Authors
Kayıkçı, Ömür; Mehtap, Özgür; Sarı, İsmail; Demirkan, Fatih; Beyan, Cengiz; Çetin, Güven; Vural, Filiz; Yılmaz, Mehmet; Öztürk, Erman; Akpınar, Seval; Eser, Bülent; Gündüz, Mehmet; Büyükaşık, Yahya; Payzın, Bahriye; Yıldırım, Rahşan; Doğu, Mehmet Hilmi; Özkan, Atilla; Kelkitli, Engin; Tekgündüz, Emre
- Abstract
Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event-free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy.
- Subjects
RESEARCH; HEMATOLOGY; RETROSPECTIVE studies; EXPERIENCE; TREATMENT effectiveness; SYMPTOMS; PATIENT education; SALVAGE therapy; HEMATOPOIETIC stem cell transplantation; T-cell lymphoma; LONGITUDINAL method
- Publication
Turkish Journal of Hematology, 2022, Vol 39, Issue 3, p170
- ISSN
1300-7777
- Publication type
Article
- DOI
10.4274/tjh.galenos.2022.2022.0052