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- Title
Larger laboratory scale synthesis of 5-methyluridine and formal synthesis of its L-enantiomer.
- Authors
Thiesen, Luciano J. Hoeltgebaum; Cabral, Nadia; e Silva, Maria Joselice; Bezerra, Gilson; Doboszewski, Bogdan
- Abstract
A larger laboratory scale synthesis (>60 g per run) of 5-methyluridine is presented. The critical intermediate 1,2-O-isopropylidene-α-D-ribofuranose was prepared from very cheap D-glucose via D-allose. Its L-enantiomer was obtained from L-arabinose via L-glucose, and also from L-xylose.
- Subjects
NUCLEOSIDE synthesis; PYRIMIDINE nucleosides; ENANTIOMERS analysis; STEREOSELECTIVE reactions; XYLOSE; REVERSE transcriptase
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2017, Vol 2017, p249
- ISSN
1551-7004
- Publication type
Article
- DOI
10.3998/ark.5550190.0018.400