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- Title
HOSPITAL OUTCOMES OF ADULT RESPIRATORY TRACT INFECTIONS WITH EXTENDED-SPECTRUM B-LACTAMASE (ESBL) PRODUCING KLEBSIELLA PNEUMONIAE.
- Authors
Li-Cher Loh; Abdul Samad, Nor Izran Hanim bt; Mohd Sani, Rosdara Masayuni bt; Raman, Sree; Thayaparan, Tarmizi; Kumar, Shalini
- Abstract
Klebsiella pneumoniae ranks high as a cause of adult pneumonia requiring hospitalization in Malaysia. To study whether extended-spectrum b-lactamase (ESBL) producing K. pneumoniae was linked to hospital outcomes, we retrospectively studied 441 cases of adult respiratory tract infections with microbial proven K. pneumoniae from an urban-based university teaching hospital between 2003 and 2004. 47 (10.6%) cases had ESBL. Requirement for ventilation and median length of hospital stay, were greater in 'ESBL' than in 'non-ESBL' group [34% vs. 7.4%, p<0.001; 14 days vs. 5 days, p<0.001 respectively] but not crude hospital mortality rate [21.3% vs. 12.4%, p=0.092]. There was a four-fold increased risk of requiring ventilation [4.61 (2.72-7.85)] when ESBL was present. Our findings support the association of ESBL producing K. pneumoniae with adversed hospital outcomes and reiterate the need for vigilance on the part of treating clinicians.
- Subjects
MALAYSIA; RESPIRATORY infections in old age; KLEBSIELLA pneumoniae; ARTIFICIAL respiration; MORTALITY
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, Issue 2, p36
- ISSN
1394-195X
- Publication type
Article