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- Title
Activation of NF-κΒ/Rel transcription factors in human primary peripheral blood mononuclear cells by interleukin 7.
- Authors
Lamberti, Annalisa; Petrella, Antonello; Pascale, Maria; Romano, Maria Fiammetta; Bisogni, Rita; Vita, Natalio; Venuta, Salvatore; Turco, Maria Caterina
- Abstract
Pathways that regulate the activation of NF-κ B/Rel transcription factors are known to include signaling through a number of cytokine receptors. Interleukin 7 (IL-7), produced by bone marrow and other stromal cells, is a key factor for differentiation and survival in the lymphoid and other compartments. We found that human recombinant IL-7 induced NF-κ B/Rel activation, analyzed by electro-phoretic mobility shift assay (EMSA), in human peripheral blood T lymphocytes from healthy donors. Induced complexes included p65 and p50 NF-κ B/Rel subunits. These results demonstrate for the first time that IL-7 can participate in signaling leading to NF-κ B/Rel activation.
- Subjects
NF-kappa B; TRANSCRIPTION factors; INTERLEUKINS; BONE marrow; LYMPHOID tissue; CELL differentiation
- Publication
Biological Chemistry, 2004, Vol 385, Issue 5, p415
- ISSN
1431-6730
- Publication type
Article