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- Title
Evaluation of Rod-Shaped Nanoparticles as Carriers for Gene Delivery.
- Authors
Fan, Min‐Min; Zhang, Wan‐Zhen; Cheng, Cong; Liu, Yan; Li, Bang‐Jing; Sun, Xun; Zhang, Sheng
- Abstract
Fabrication of nonspherical particles for gene delivery remains a major challenge. In this study, novel rod-like nanoparticles are prepared for efficient gene delivery by self-assembly of α-cyclodextrin (α-CD) and polyethylenimine-methoxy poly(ethylene glycol) (PEI-mPEG). The study reveals that the rod-like PEI-mPEG/α-CD particles can bind DNA effectively and the resulting PEI-mPEG/α-CD/DNA complexes show over four times higher gene delivery capability than their spherical counterparts and PEI(25K) due to more efficient cellular uptake. Furthermore, the cytotoxicity of rod-like PEI-mPEG/α-CD is about five times lower than that of the nanospheres, and 50 times lower than that of DNA/PEI(25K). These results indicate that shape is an important parameter for the design of gene delivery vectors.
- Subjects
NANOPARTICLES; GENE delivery techniques; CYCLODEXTRINS; DNA-binding proteins; COMPLEX compounds
- Publication
Particle & Particle Systems Characterization, 2014, Vol 31, Issue 9, p994
- ISSN
0934-0866
- Publication type
Article
- DOI
10.1002/ppsc.201300383