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- Title
N-containing functional groups induced superior cytocompatible and hemocompatible graphene by NH<sub>2</sub> ion implantation.
- Authors
Guo, Meixian; Li, Minsi; Liu, Xiaoqi; Zhao, Mengli; Li, Dejun; Geng, Dongsheng; Sun, Xueliang; Gu, Hanqing
- Abstract
Graphene is functionalized with amine by NH 2 ion implantation at room temperature in vacuum. The reaction is featured by nucleophilic substitution of C–O groups by the ammonia radicals. The presence of N-containing functional groups in graphene is identified by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. N element was successfully introduced to graphene, the atomic ratio of N to C rose to 3.12 %. NH 2 ion implanted graphene (G-NH 2) is a better hydrophilic material than pristine grahene according to the contact angle experiment. Mouse fibroblast cells and human endothelial cells cultured on G-NH 2 displayed superior cell-viability, proliferation and stretching over that on pristine graphene. Platelet adhesion, hemolysis and Kinetic-clotting time were measured on G-NH 2, showing excellent anticoagulation, with as good hemolysis as pristine graphene.
- Subjects
GRAPHENE; ION implantation; FUNCTIONAL groups; NUCLEOPHILIC substitution reactions; FIBROBLASTS; LABORATORY mice; ANTICOAGULANTS
- Publication
Journal of Materials Science: Materials in Medicine, 2013, Vol 24, Issue 12, p2741
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-013-5016-0