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- Title
Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms.
- Authors
Campos, Jonas; Silva, Nuno A; Salgado, António J
- Abstract
Spinal cord injury (SCI) is a debilitating condition that leads to motor, sensory, and autonomic impairments. Its intrinsic pathophysiological complexity has hindered the establishment of effective treatments for decades. Nutritional interventions (NIs) for SCI have been proposed as a route to circumvent some of the problems associated with this condition. Results obtained in animal models point to a more holistic effect, rather than to specific modulation, of several relevant SCI pathophysiological processes. Indeed, published data have shown NI improves energetic imbalance, oxidative damage, and inflammation, which are promoters of improved proteostasis and neurotrophic signaling, leading ultimately to neuroprotection and neuroplasticity. This review focuses on the most well-documented Nis. The mechanistic implications and their translational potential for SCI are discussed.
- Subjects
NEUROLOGICAL disorder prevention; DRUG efficacy; PROTEINS; HOMEOSTASIS; SPINAL cord injuries; PHENOLS; NEUROPLASTICITY; METABOLISM; REDUCING diets; DIET therapy; MOLECULAR biology; NEUROPROTECTIVE agents; OMEGA-3 fatty acids; PLANT extracts; MEDICAL research; DISEASE complications
- Publication
Nutrition Reviews, 2022, Vol 80, Issue 5, p1206
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1093/nutrit/nuab068